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The Method N° 04 · How muscle grows

Exercise choice

Equipment and order matter less than you think. Different exercises grow different parts of a muscle.

Every study checked against the paper, . Each section carries its grade. Run the numbers in the app.

Machines or free weights

Strong

Free weights and machines built similar muscle across 13 studies, and each made people strongest at the kind of lift they trained.1 In an eight-week trial of 46 people, biceps and quadriceps grew the same either way.2

Wobble boards add nothing

Still open

Squatting on an unstable board grew no more muscle than a Smith machine or a free squat.3 One trial, and nothing argues the other way.

Order shapes strength, not size

Strong

Across 11 studies, exercise order made no difference to growth, but people gained the most strength on whatever came first.4

Muscles grow unevenly

Strong

A muscle does not grow evenly along its length: 13 of 14 studies found some regions grew more than others,5 and in the triceps the regions that grew most were the ones worked hardest.6

So a second exercise earns its place

Strong

Leg extensions grew all three regions measured in the rectus femoris, while squats grew only the middle of the outer quad.7 Groups given a planned mix of exercises grew at every site measured; groups kept on one missed some.8,9

The stretch matters

Strong

Training a muscle where it is long tends to grow it at least as well. Seated leg curls, which stretch the hamstrings, grew them 14% against 9% for lying curls,10 and overhead triceps work grew the triceps 19.9% against 13.9%.11 Pooled across 12 studies the difference shrinks to similar, with a slight lean toward long lengths.12

Variety for its own sake does not help

Still open

Planned variation can fill regional gaps, but rotating exercises at random neither clearly helps nor hurts growth,13,14 though in one trial it made people keener to train.15

How the Vanguard app runs this

Every movement in the app's library is tagged with the one muscle it counts toward and where it loads it hardest: long, mid-range or short. A swap only ever offers movements that train the same muscle.

The research

The research

The 15 sources this chapter stands on, with what each one actually found.

  1. Haugen, Vårvik, Larsen et al., 2023 · BMC Sports Sci Med Rehabil

    Meta-analysis · 13 studies · 1,016 people

    No difference in muscle growth between free weights and machines (effect −0.055), measured in 5 of the studies; strength gains followed the mode trained.

    Read the paper by Haugen, Vårvik, Larsen et al., 2023 (opens in a new tab)
  2. Schwanbeck, Cornish, Barss et al., 2020 · J Strength Cond Res

    Randomised trial · n = 46 · 8 weeks

    Biceps and quadriceps thickness grew similarly with free weights and with machines.

    Read the paper by Schwanbeck, Cornish, Barss et al., 2020 (opens in a new tab)
  3. Saeterbakken, Olsen, Behm et al., 2019 · PLoS One

    Randomised trial · n = 59 men · 7 weeks

    Smith machine, free-weight and wobble-board squat groups gained similar muscle thickness.

    Read the paper by Saeterbakken, Olsen, Behm et al., 2019 (opens in a new tab)
  4. Nunes, Grgic, Cunha et al., 2021 · Eur J Sport Sci

    Meta-analysis · 11 studies

    Order made no difference to growth (effect 0.03); multi-joint strength favoured multi-joint lifts first (0.32), single-joint strength single-joint first.

    Read the paper by Nunes, Grgic, Cunha et al., 2021 (opens in a new tab)
  5. Zabaleta-Korta, Fernández-Peña, Santos-Concejero, 2020 · Strength Cond J

    Systematic review · 14 studies

    13 of 14 studies found some regions of a muscle grew more than others.

    Read the paper by Zabaleta-Korta, Fernández-Peña, Santos-Concejero, 2020 (opens in a new tab)
  6. Wakahara, Fukutani, Kawakami et al., 2013 · Med Sci Sports Exerc

    Training study · n = 12 · 12 weeks

    The regions of the triceps that grew most were the ones most activated in training.

    Read the paper by Wakahara, Fukutani, Kawakami et al., 2013 (opens in a new tab)
  7. Zabaleta-Korta, Fernández-Peña, Torres-Unda et al., 2021 · J Sports Sci

    Randomised trial

    Leg extensions grew all three regions of the rectus femoris; Smith-machine squats grew only the central outer quad.

    Read the paper by Zabaleta-Korta, Fernández-Peña, Torres-Unda et al., 2021 (opens in a new tab)
  8. Costa, Kassiano, Nunes et al., 2021 · Int J Sports Med

    Randomised trial · n = 22 detrained men · 9 weeks

    The varied-exercise group grew at every site measured; the fixed group did not grow at two of them.

    Read the paper by Costa, Kassiano, Nunes et al., 2021 (opens in a new tab)
  9. Fonseca, Roschel, Tricoli et al., 2014 · J Strength Cond Res

    Training study · n = 49 · 12 weeks

    Varied-exercise groups grew all four heads of the quadriceps; constant-exercise groups missed some.

    Read the paper by Fonseca, Roschel, Tricoli et al., 2014 (opens in a new tab)
  10. Maeo, Huang, Wu et al., 2021 · Med Sci Sports Exerc

    Training study · seated against lying leg curl

    Hamstrings grew 14% with the seated curl, which trains them long, against 9% with the lying curl.

    Read the paper by Maeo, Huang, Wu et al., 2021 (opens in a new tab)
  11. Maeo, Wu, Huang et al., 2023 · Eur J Sport Sci

    Training study · overhead against neutral-arm extensions

    Whole triceps volume grew 19.9% overhead against 13.9% with the arm at the side.

    Read the paper by Maeo, Wu, Huang et al., 2023 (opens in a new tab)
  12. Varovic, Wolf, Schoenfeld et al., 2025 · Int J Sports Med

    Meta-analysis · 12 studies

    Training at long and short muscle lengths produced similar growth, with a trivial lean toward long lengths near the far end of the muscle.

    Read the paper by Varovic, Wolf, Schoenfeld et al., 2025 (opens in a new tab)
  13. Kassiano, Nunes, Costa et al., 2022 · J Strength Cond Res

    Systematic review · 8 studies · 241 men

    Planned variation may help regional growth; excessive random rotation may hurt it.

    Read the paper by Kassiano, Nunes, Costa et al., 2022 (opens in a new tab)
  14. Kassiano, Costa, Kunevaliki et al., 2025 · Res Q Exerc Sport

    Randomised trial · n = 70 women · 10 weeks

    Varied and constant exercise selection grew muscle alike (7.8 to 17.7% against 7.5 to 19.3%).

    Read the paper by Kassiano, Costa, Kunevaliki et al., 2025 (opens in a new tab)
  15. Baz-Valle, Schoenfeld, Torres-Unda et al., 2019 · PLoS One

    n = 21 trained men · 8 weeks

    Randomising exercises each session gave similar gains and raised motivation to train.

    Read the paper by Baz-Valle, Schoenfeld, Torres-Unda et al., 2019 (opens in a new tab)

Research describes groups of people. Your coach will tell you how it applies to you.